| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology, The University of Melbourne
2 Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3010, Australia
Understanding genetic factors that contribute to population-wide variation in blood pressure is likely to benefit prevention and treatment of cardiovascular disease. The aim of the Victorian Family Heart Study is to identify genes for cardiovascular risk in 783 volunteer adult families recruited from the general population. In this preliminary study we sought to identify quantitative trait loci (QTLs) using a genome-wide linkage analysis in 274 adult sibling pairs of average age 24 yr selected without respect to blood pressure. We compared multipoint linkage results for carefully measured systolic (SBP) and diastolic (DBP) pressures before and after statistical adjustment for covariation with sex, oral contraception, age, height, and weight. The average BP was 123/67 (SD: 12/11) mmHg in males (n = 283) and 114/64 (SD: 10/9) mmHg in females (n = 265). Nonparametric Z-scores from multipoint GeneHunter II analysis were "suggestive" (3.1 or more) at four QTLs for SBP (chromosomes 1, 4, 16, and X) but at no QTLs for DBP. Most Z-scores were affected little by adjustment for covariates. However, the SBP QTL on chromosome 16 was obvious only for unadjusted pressures. This population-based quantitative trait analysis has identified more QTLs than any of the eight previous genome-wide scans for blood pressure. Considerable discrepancies between different studies may reflect the presence of false-positive results or real biological differences between populations.
quantitative trait loci; systolic blood pressure; cardiovascular risk
This article has been cited by other articles:
|
|
 |
|
  C. J. Busst, K. J. Scurrah, J. A. Ellis, and S. B. Harrap Selective Genotyping Reveals Association Between the Epithelial Sodium Channel {gamma}-Subunit and Systolic Blood Pressure Hypertension, October 1, 2007; 50(4): 672 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yatsu, N. Mizuki, N. Hirawa, A. Oka, N. Itoh, T. Yamane, M. Ogawa, T. Shiwa, Y. Tabara, S. Ohno, et al. High-Resolution Mapping for Essential Hypertension Using Microsatellite Markers Hypertension, March 1, 2007; 49(3): 446 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Franceschini, J. W. MacCluer, H. H.H. Goring, S. A. Cole, K. M. Rose, L. Almasy, V. Diego, S. Laston, E. T. Lee, B. V. Howard, et al. A Quantitative Trait Loci-Specific Gene-by-Sex Interaction on Systolic Blood Pressure Among American Indians: The Strong Heart Family Study Hypertension, August 1, 2006; 48(2): 266 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Bell, C. Wallace, R. Dobson, S. Wiltshire, C. Mein, J. Pembroke, M. Brown, D. Clayton, N. Samani, A. Dominiczak, et al. Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension Hum. Mol. Genet., April 15, 2006; 15(8): 1365 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Bielinski, A. I. Lynch, M. B. Miller, A. Weder, R. Cooper, A. Oberman, Y.-D. I. Chen, S. T. Turner, M. Fornage, M. Province, et al. Genome-Wide Linkage Analysis for Loci Affecting Pulse Pressure: The Family Blood Pressure Program Hypertension, December 1, 2005; 46(6): 1286 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Duggal, A. P. Klein, K. E. Lee, S. K. Iyengar, R. Klein, J. E. Bailey-Wilson, and B. E. K. Klein A Genetic Contribution to Intraocular Pressure: The Beaver Dam Eye Study Invest. Ophthalmol. Vis. Sci., February 1, 2005; 46(2): 555 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Martin, A. G. Comuzzie, G. E. Sonnenberg, J. Myklebust, R. James, J. Marks, J. Blangero, and A. H. Kissebah Major Quantitative Trait Locus for Resting Heart Rate Maps to a Region on Chromosome 4 Hypertension, May 1, 2004; 43(5): 1146 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Mein, M. J. Caulfield, R. J. Dobson, and P. B. Munroe Genetics of essential hypertension Hum. Mol. Genet., April 1, 2004; 13(90001): R169 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Harrap, J. S. Cui, Z. Y. H. Wong, and J. L. Hopper Familial and Genomic Analyses of Postural Changes in Systolic and Diastolic Blood Pressure Hypertension, March 1, 2004; 43(3): 586 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. von Wowern, K. Bengtsson, C. M. Lindgren, M. Orho-Melander, F. Fyhrquist, U. Lindblad, L. Rastam, C. Forsblom, T. Kanninen, P. Almgren, et al. A genome wide scan for early onset primary hypertension in Scandinavians Hum. Mol. Genet., August 15, 2003; 12(16): 2077 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Cui, J. L. Hopper, and S. B. Harrap Antihypertensive Treatments Obscure Familial Contributions to Blood Pressure Variation Hypertension, February 1, 2003; 41(2): 207 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cui, J. L. Hopper, and S. B. Harrap Genes and Family Environment Explain Correlations Between Blood Pressure and Body Mass Index Hypertension, July 1, 2002; 40(1): 7 - 12. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
