Physiol. Genomics Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Genomics 8: 81-86, 2002. First published December 4, 2001; doi:10.1152/physiolgenomics.00080.2001
1094-8341/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
8/2/81    most recent
00080.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garrett, M. R.
Right arrow Articles by Rapp, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garrett, M. R.
Right arrow Articles by Rapp, J. P.
Received 10 September 2001; accepted in final form 27 November 2001.
Physiological Genomics 8:81-86 (2002)
1094-8341/02 $5.00 © 2002 American Physiological Society

Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats

Michael R. Garrett and John P. Rapp

Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614

Previously we reported the construction of a congenic strain, S.LEW(5), spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S.LEW(5) which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart.

hypertension; quantitative trait loci; genetic hypertension




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
B. Joe, Y. Saad, N. H. Lee, B. C. Frank, O. H. Achinike, T. V. Luu, K. Gopalakrishnan, E. J. Toland, P. Farms, S. Yerga-Woolwine, et al.
Positional identification of variants of Adamts16 linked to inherited hypertension
Hum. Mol. Genet., August 1, 2009; 18(15): 2825 - 2838.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. Flint and T. F.C. Mackay
Genetic architecture of quantitative traits in mice, flies, and humans
Genome Res., May 1, 2009; 19(5): 723 - 733.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. M. Williams, A. Sarkis, K. M. Hoagland, K. Fredrich, R. P. Ryan, C. Moreno, B. Lopez, J. Lazar, F. J. Fenoy, M. Sharma, et al.
Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury
Am J Physiol Renal Physiol, December 1, 2008; 295(6): F1764 - F1777.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
N. H. Lee, B. J. Haas, N. E. Letwin, B. C. Frank, T. V. Luu, Q. Sun, C. D. House, S. Yerga-Woolwine, P. Farms, E. Manickavasagam, et al.
Cross-Talk of Expression Quantitative Trait Loci Within 2 Interacting Blood Pressure Quantitative Trait Loci
Hypertension, December 1, 2007; 50(6): 1126 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
A. Y. Deng
Genetic basis of polygenic hypertension
Hum. Mol. Genet., October 15, 2007; 16(R2): R195 - R202.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. J. Lee, J. Liu, A. M. Westcott, J. A. Vieth, S. J. DeRaedt, S. Yang, B. Joe, and G. T. Cicila
Substitution Mapping in Dahl Rats Identifies Two Distinct Blood Pressure Quantitative Trait Loci Within 1.12- and 1.25-Mb Intervals on Chromosome 3
Genetics, December 1, 2006; 174(4): 2203 - 2213.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. J. Roman, K. M. Hoagland, B. Lopez, A. E. Kwitek, M. R. Garrett, J. P. Rapp, J. Lazar, H. J. Jacob, and A. Sarkis
Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1463 - F1471.
[Abstract] [Full Text] [PDF]

Home page
 Phil Trans R Soc BHome page
R. Mott
Finding the molecular basis of complex genetic variation in humans and mice
Phil Trans R Soc B, March 29, 2006; 361(1467): 393 - 401.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. Gauguier, J. Behmoaras, K. Argoud, S. P. Wilder, C. Pradines, M. T. Bihoreau, M. Osborne-Pellegrin, and M. P. Jacob
Chromosomal Mapping of Quantitative Trait Loci Controlling Elastin Content in Rat Aorta
Hypertension, March 1, 2005; 45(3): 460 - 466.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. A. Mein, M. J. Caulfield, R. J. Dobson, and P. B. Munroe
Genetics of essential hypertension
Hum. Mol. Genet., April 1, 2004; 13(90001): R169 - 175.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. W. McBride, F. J. Charchar, D. Graham, W. H. Miller, P. Strahorn, F. J. Carr, and A. F. Dominiczak
Functional genomics in rodent models of hypertension
J. Physiol., January 1, 2004; 554(1): 56 - 63.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. W. McBride, F. J. Carr, D. Graham, N. H. Anderson, J. S. Clark, W. K. Lee, F. J. Charchar, M. J. Brosnan, and A. F. Dominiczak
Microarray Analysis of Rat Chromosome 2 Congenic Strains
Hypertension, March 1, 2003; 41(3): 847 - 853.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online