HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 8/2/151    most recent 00102.2001v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (21) Citing Articles via Google Scholar Google Scholar Articles by Rankinen, T. Articles by Bouchard, C. Search for Related Content PubMed PubMed Citation Articles by Rankinen, T. Articles by Bouchard, C.

G protein ß3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study

¹ Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808-4124
² Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110
³ School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, Minnesota 55455
⁴ Department of Kinesiology, Indiana University, Bloomington, Indiana 46405
⁵ Department of Health and Kinesiology, Texas A & M University, College Station, Texas 77843-4243
⁶ Departments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110-1093

A C825T polymorphism of the G protein ß3 (GNB3) gene has been reported to be associated with hypertension and obesity. We analyzed the associations between the GNB3 C825T polymorphism and hemodynamic and body composition phenotypes in the sedentary state and their responses to endurance training in mainly normotensive white (n = 473) and black (n = 255) men and women. Blood pressure (BP) and heart rate (HR) were measured at rest and during submaximal exercise at constant power output (50 W), and stroke volume and cardiac output were obtained during exercise. Body composition was assessed with underwater weighing. Baseline systolic BP (SBP) at 50 W was slightly higher in the white CC homozygotes (P = 0.036), whereas in blacks the CC genotype was associated with a lower resting HR (P = 0.012). In blacks, the CC homozygotes showed a greater training-induced reduction in HR at 50 W (P = 0.013) and a similar trend was observed also in whites (P = 0.053). Black women carrying the CC genotype showed significantly greater reductions in resting SBP and diastolic BP (DBP) than the TT homozygotes, whereas in black men the changes in resting BP were similar across the genotypes (P < 0.05 for sex-by-GNB3 interactions). The GNB3 genotype was not associated with baseline body composition in blacks or whites. In blacks, the TT genotype was associated with a greater training-induced decrease in fat mass (P = 0.012) and percent body fat (P = 0.006). These data suggest that DNA sequence variation in the GNB3 locus is not a major modifier of endurance training-induced changes in hemodynamic and body composition phenotypes in healthy but previously sedentary subjects. The GNB3 genotype may play a minor role in HR and body fatness regulation in blacks and in responsiveness of resting BP to endurance training in black women.

blood pressure; heart rate; body fatness; exercise training; genotype

This article has been cited by other articles:

				N. Eynon, J. Oliveira, Y. Meckel, M. Sagiv, C. Yamin, M. Sagiv, R. Amir, and J. A. Duarte The guanine nucleotide binding protein \#946; polypeptide 3 gene C825T polymorphism is associated with elite endurance athletes Exp Physiol, March 1, 2009; 94(3): 344 - 349. [Abstract] [Full Text] [PDF]

				S. M. Roth Perspective on the future use of genomics in exercise prescription J Appl Physiol, April 1, 2008; 104(4): 1243 - 1245. [Full Text] [PDF]

				M. Liang and B. Ventura Physiological genomics in PG and beyond: July to September 2005 Physiol Genomics, October 17, 2005; 23(2): 119 - 124. [Full Text] [PDF]

				E. H. Sklan, A. Lowenthal, M. Korner, Y. Ritov, D. M. Landers, T. Rankinen, C. Bouchard, A. S. Leon, T. Rice, D. C. Rao, et al. Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study PNAS, April 13, 2004; 101(15): 5512 - 5517. [Abstract] [Full Text] [PDF]