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Physiol. Genomics 7: 159-169, 2001. First published October 16, 2001; doi:10.1152/physiolgenomics.00041.2001
1094-8341/01 $5.00
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Received 1 June 2001; accepted in final form 24 October 2001.
Physiological Genomics 7:159-169 (2001)
1094-8341/01 $5.00 © 2001 American Physiological Society

Influence of ethanol on thermoregulation: mapping quantitative trait loci

LARRY I. CRAWSHAW1,2, HELEN L. WALLACE1, ROBIN CHRISTENSEN1 and JOHN C. CRABBE2

1 Department of Biology, Portland State University, Portland, 97207
2 Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, Oregon 97201

The genetic basis for the effects of ethanol on thermoregulation was investigated by utilizing recombinant inbred mouse strains from C57BL/6J and DBA/2J progenitor strains. Changes in core body temperature (Tc) and the degree of fluctuation of Tc were monitored in male mice following the administration of ethanol in an environment with cyclic changes in ambient temperature (Ta). Changes in Tc were utilized to assess ethanol-induced effects on regulated Tc, whereas fluctuations in Tc were utilized to assess thermoregulatory disruption. Ethanol was administered intraperitoneally at 1.5, 2.5, and 3.5 g/kg for all strains. Change in Tc and increase in tail temperature were also evaluated at 2.5 g/kg ethanol in a constant Ta of 26°C. Associations between the measured physiological responses and previously mapped genetic markers were used to identify quantitative trait loci (QTLs). This established probable chromosome locations for a number of genes for the responses. To our knowledge, this is the first report of QTLs that underlie changes in regulation as well as the disruption of a physiological regulatory system.

alcohol; temperature regulation; recombinant inbred strains; genetics




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