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Physiol. Genomics 7: 127-134, 2001; doi:10.1152/physiolgenomics.00089.2001
1094-8341/01 $5.00
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Received 20 December 2000; accepted in final form 6 September 2001.
Physiological Genomics 7:127-134 (2001)
1094-8341/01 $5.00 © 2001 American Physiological Society

Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype

CARLA SOMMARDAHL1, MARILYN COTTRELL1, J. ERBY WILKINSON1, RICHARD P. WOYCHIK2 and DABNEY K. JOHNSON3

1 Department of Pathology and Department of Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee 37901-1071
2 Lynx Therapeutics, Hayward, California 94545
3 Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831

The Oak Ridge polycystic kidney (orpk) mutant mouse model resulted from a transgene insertion into the Tg737 gene and exhibits a pleiotropic syndrome with lesions in the kidney, liver, and pancreas. We found marked differences in the phenotypic expression of the orpk mutation when bred on different genetic backgrounds. In the FVB/N background, the phenotype is very severe for kidney, pancreas, and liver lesions. To evaluate better how genetic background might influence the expressivity of the orpk phenotype, we bred the transgene into the C3HeB/FeJLe (C3H) genetic background. We performed a genome-wide scan using backcross and intercross populations with more than 150 markers to map the chromosomal location of the modifier genes that differ in the FVB/N and C3H genetic backgrounds that affect the severity of kidney disease in the orpk mouse. Low-resolution interval mapping was performed using the Map Manager QTb program, with the interval explaining a significant portion of the variance being the distal end of chromosome 4.

polycystic kidney disease; biliary hyperplasia; pancreatic cysts




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