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Physiol. Genomics 6: 3-9, 2001;
1094-8341/01 $5.00
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Received 3 January 2001; accepted in final form 3 April 2001.
Physiological Genomics 6:3-9 (2001)
1094-8341/01 $5.00 © 2001 American Physiological Society

Further chromosomal mapping of a blood pressure QTL in Dahl rats on chromosome 2 using congenic strains

JULIE DUTIL and ALAN Y. DENG

Research Centre, Centre Hospitalier de l’Université de Montreal, Montreal, Quebec, H2W 1T8, Canada

Both linkage and use of congenic strains have shown that a region on rat chromosome 2 (Chr 2) of Dahl salt-sensitive rats (S) contained a quantitative trait locus (QTL) for blood pressure (BP). A congenic strain was made by replacing a segment of the S rat by the homologous region of the Milan normotensive (MNS) rat. Since the region was roughly 80 cM in size, a further reduction is required toward the final identification of the QTL. Currently, three congenic substrains were made by replacing smaller sections within the 80 cM. Each strain contains a specific region of MNS in the S genetic background. Two of the three congenic strains shared a segment in common, and both showed a BP-lowering effect. One of the three congenic strains carried a unique segment and had the same BP as S. Deducing the fragment shared in the two substrains having an effect, the BP QTL has to be present in a region of roughly 15 cM. In contrast to BP, heart rates of all the congenic rats were the same as that of the S rat. Thus BP and the heart rate are under the control of independent genetic determinants.

genetic hypertension; rat chromosome 2; Milan normotensive rat; quantitative trait locus




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