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Physiol. Genomics 6: 11-18, 2001;
1094-8341/01 $5.00
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Received 18 December 2000; accepted in final form 4 April 2001.
Physiological Genomics 6:11-18 (2001)
1094-8341/01 $5.00 © 2001 American Physiological Society

Mapping of microsatellite loci and association of aorta atherosclerosis with LG VI markers in the rabbit

R. KORSTANJE, G. F. GILLISSEN, L. P. KODDE, M. DEN BIEMAN, A. LANKHORST, L. F. M. VAN ZUTPHEN and H. A. VAN LITH

Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands

Twenty-three rabbit microsatellites were extracted from the EMBL nucleotide database. Nine of these markers, together with nine earlier published microsatellite markers, were found to be polymorphic between the AX/JU and IIIVO/JU inbred strains. By using an F2 intercross we could integrate five markers into the rabbit linkage map. One anonymous microsatellite marker could be assigned to chromosome 1, and one microsatellite marker, located within the metallothionein-1 gene, could be added to linkage group VI (LG VI). Three microsatellite markers (one anonymous, one located within the PMP2 gene, and one located within the FABP6 gene) constitute a new linkage group (LG XI). We also measured the degree of dietary cholesterol-induced aorta atherosclerosis in the F2 animals. A significant cosegregation was found between the degree of aorta atherosclerosis and the allelic variation of the biochemical marker Est-2 on LG VI in male rabbits. This association was not found in female rabbits.

atherosclerosis; genetic map; quantitative trait locus; microsatellite




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R. Korstanje, G. F. Gillissen, S. A. Versteeg, B. A. van Oost, A. A. Bosma, C. Rogel-Gaillard, L. F. M. van Zutphen, and H. A. van Lith
Mapping of Rabbit Microsatellite Markers Using Chromosome-Specific Libraries
J. Hered., March 1, 2003; 94(2): 161 - 169.
[Abstract] [Full Text] [PDF]


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