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Physiol. Genomics 4: 175-181, 2001;
1094-8341/01 $5.00
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Received 14 August 2000; accepted in final form 6 November 2000.
Physiological Genomics 4:175-181 (2001)
1094-8341/01 $5.00 © 2001 American Physiological Society

Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat

D. D. FULLER, T. L. BAKER, M. BEHAN and G. S. MITCHELL

Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706

Long-term facilitation (LTF) is a prolonged, serotonin-dependent augmentation of respiratory motor output following episodic hypoxia. Previous observations lead us to hypothesize that LTF is subject to genetic influences and, as a result, differs between Sprague-Dawley (SD) rats from two vendors, Harlan (H) and Charles River Laboratories/Sasco (CRL/S). Using a blinded experimental design, we recorded integrated phrenic ({int}Phr) and hypoglossal neurograms in anesthetized, vagotomized, paralyzed, and ventilated rats. At 60 min following three 5-min hypoxic episodes (PaO2 = 40 ± 1 Torr; 5-min hyperoxic intervals), {int}Phr was elevated from baseline in both SD substrains (i.e., LTF; P < 0.05). Conversely, hypoglossal LTF was present in CRL/S but not H rats (P < 0.05 between substrains). Serotonin immunoreactivity within the hypoglossal nucleus was not different between H and CRL/S rats. We conclude that the expression of hypoglossal LTF differs between SD rat substrains, indicating a difference in their genetic predisposition to neural plasticity.

respiratory control; plasticity; genetics




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