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Physiol. Genomics 4: 155-164, 2000;
1094-8341/00 $5.00
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Received 23 June 2000; accepted in final form 6 October 2000.
Physiological Genomics 4:155-164 (2000)
1094-8341/00 $5.00 © 2000 American Physiological Society

Gene expression profiling of mouse postnatal cerebellar development

RYO MATOBA1,2, SAKAE SAITO1,2, NORIKO UENO1, CHIYURI MARUYAMA1,2, KENICHI MATSUBARA1,2 and KIKUYA KATO1,2

1 Taisho Laboratory of Functional Genomics, Nara Institute of Science and Technology
2 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 8916-5 Takayama, Ikoma, Nara, 630-0101, Japan

Expression patterns of 1,869 genes were determined using adapter-tagged competitive PCR (ATAC-PCR) at 6 time points during mouse postnatal cerebellar development. The expression patterns were classified into 12 clusters that were further assembled into 3 groups by hierarchical cluster analysis. Among the 1,869 genes, 1,053 known genes were assigned to 90 functional categories. Statistically significant correlation between the clusters or groups of gene expression and the functional categories was ascertained. Genes involved in oncogenesis or protein synthesis were highly expressed during the earlier stages of development. Those responsible for brain functions such as neurotransmitter receptor and synapse components were more active during the later stages of development. Many other genes also showed expression patterns in accordance with literature information. The gene expression patterns and the inferred functions were in good agreement with anatomical as well as physiological observations made during the developmental process.

adapter-tagged competitive polymerase chain reaction; cluster analysis; SwissProt database




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