Physiol. Genomics AJP: Advances in Physiology Education
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Physiol. Genomics 35: 199-209, 2008. First published September 23, 2008; doi:10.1152/physiolgenomics.90249.2008
1094-8341/08 $8.00
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Received 14 May 2008; accepted in final form 16 September 2008.
Physiological Genomics 35:199-209 (2008)
1094-8341/08 $8.00 © 2008 American Physiological Society

Call For Papers: Comparative Genomics

Mapping of quantitative trait loci for cholesterol, LDL, HDL, and triglyceride serum concentrations in pigs

David Gallardo 1,*, Ramona N. Pena 2,*, Marcel Amills 1, Luis Varona 2, Oscar Ramírez 1, Josep Reixach 3, Isabel Díaz 4, Joan Tibau 5, Joaquim Soler 5, Josep M. Prat-Cuffi 6, José L. Noguera 2 and Raquel Quintanilla 2

1 Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra
2 Genètica i Millora Animal, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Lleida
3 Selección Batallé S.A., Riudarenes
4 Tecnologia dels Aliments, IRTA, Monells
5 Control i Avaluació de Porcí, IRTA, Monells
6 Laboratori d'Anàlisis Clíniques, Hospital de Palamós, Palamós, Spain

The fine mapping of polymorphisms influencing cholesterol (CT), triglyceride (TG), and lipoprotein serum levels in human and mouse has provided a wealth of knowledge about the complex genetic architecture of these traits. The extension of these genetic analyses to pigs would be of utmost importance since they constitute a valuable biological and clinical model for the study of coronary artery disease and myocardial infarction. In the present work, we performed a whole genome scan for serum lipid traits in a half-sib Duroc pig population of 350 individuals. Phenotypic registers included total CT, TG, and low (LDL)- and high (HDL)-density lipoprotein serum concentrations at 45 and 190 days of age. This approach allowed us to identify two genomewide significant quantitative trait loci (QTL) for HDL-to-LDL ratio at 45 days (SSC6, 84 cM) and for TG at 190 days (SSC4, 23 cM) as well as a number of chromosomewide significant QTL. The comparison of QTL locations at 45 and 190 days revealed a notable lack of concordance at these two time points, suggesting that the effects of these QTL are age specific. Moreover, we have observed a considerable level of correspondence among the locations of the most significant porcine lipid QTL and those identified in humans. This finding might suggest that, in mammals, diverse polymorphisms located in a common set of genes are involved in the genetic variation of serum lipid levels.

lipoproteins; lipid metabolism; candidate genes






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