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Physiol. Genomics 34: 225-238, 2008. First published June 17, 2008; doi:10.1152/physiolgenomics.90242.2008 Free Article
1094-8341/08 $8.00
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Received 6 May 2008; accepted in final form 11 June 2008.
Physiological Genomics 34:225-238 (2008)
1094-8341/08 $8.00 © 2008 American Physiological Society

Review

Contemporary approaches for modifying the mouse genome

David J. Adams and Louise van der Weyden

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom

The mouse is a premiere experimental organism that has contributed significantly to our understanding of vertebrate biology. Manipulation of the mouse genome via embryonic stem (ES) cell technology makes it possible to engineer an almost limitless repertoire of mutations to model human disease and assess gene function. In this review we outline recent advances in mouse experimental genetics and provide a "how-to" guide for those people wishing to access this technology. We also discuss new technologies, such as transposon-mediated mutagenesis, and resources of targeting vectors and ES cells, which are likely to dramatically accelerate the pace with which we can assess gene function in vivo, and the progress of forward and reverse genetic screens in mice.

gene targeting; transposons; mutagenesis; embryonic stem cells




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