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Physiol. Genomics 33: 341-354, 2008. First published March 18, 2008; doi:10.1152/physiolgenomics.00024.2008
1094-8341/08 $8.00
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Received 28 January 2008; accepted in final form 13 March 2008.
Physiological Genomics 33:341-354 (2008)
1094-8341/08 $8.00 © 2008 American Physiological Society

Transcriptional adaptation to Clcn5 knockout in proximal tubules of mouse kidney

Jerry Wright 1, Marcelo M. Morales 2, Jackson Sousa-Menzes 2, Debora Ornellas 2, Jennifer Sipes 3, Yan Cui 3, Isabelle Cui 3, Phuson Hulamm 3, Valeriu Cebotaru 3, Liudmila Cebotaru 3, William B. Guggino 2 and Sandra E. Guggino 1,3

3 Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland
1 Department of Physiology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland
2 Instituto de Biophysica Carlos Chagas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Dent disease has multiple defects attributed to proximal tubule malfunction including low-molecular-weight proteinuria, aminoaciduria, phosphaturia, and glycosuria. To understand the changes in kidney function of the Clc5 chloride/proton exchanger gene knockout mouse model of Dent disease, we examined gene expression profiles from proximal S1 and S2 tubules of mouse kidneys. We found many changes in gene expression not known previously to be altered in this disease. Genes involved in lipid metabolism, organ development, and organismal physiological processes had the greatest number of significantly changed transcripts. In addition, genes of catalytic activity and transporter activity also had a great number of changed transcripts. Overall, 720 genes are expressed differentially in the proximal tubules of the Dent Clcn5 knockout mouse model compared with those of control wild-type mice. The fingerprint of these gene changes may help us to understand the phenotype of Dent disease.

gene array; Dent disease; cholesterol; endocytosis




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[Abstract] [Full Text] [PDF]


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