Physiol. Genomics AJP: Gastrointestinal and Liver Physiology
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Physiol. Genomics 33: 205-211, 2008. First published January 22, 2008; doi:10.1152/physiolgenomics.00222.2007
1094-8341/08 $8.00
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Received 23 September 2007; accepted in final form 16 January 2008.
Physiological Genomics 33:205-211 (2008)
1094-8341/08 $8.00 © 2008 American Physiological Society

Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks

Takashi Kuramoto, Satoshi Nakanishi and Tadao Serikawa

Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

Polymorphisms that have been proven to influence gene functions are called functional polymorphisms. It is significant to know the distribution of functional polymorphisms in the rat, widely used in animal models for human diseases. In this study, we assessed 16 functional polymorphisms consisting of 3 coat color and 13 disease-associated genes in 136 rat strains, as a part of the genetic profiling program of the National Bio Resource Project for the Rat (NBRP-Rat). Polymorphisms of Cdkn1a, Fcgr3, Grp10, Lss, and Fdft1, which were proven to function in prostate tumorigenesis, glomerulonephritis, hyperphagia, and cholesterol biosynthesis, were shared among various inbred strains. These findings indicated that most rat strains harbored the disease-associated alleles and suggested that many unidentified functional polymorphisms might exist in inbred rat strains. The functional polymorphisms shared in inbred strains were also observed within outbred stocks available commercially. Therefore, this implies that experimental plans based on either rat inbred strains or outbred stocks need to be carefully designed with a full understanding of the genetic characteristics of the animals. To select the most suitable strains for experiments, the NBRP-Rat will periodically improve and update the genetic profiles of rat strains.

rat resource; National Bio Resource Project; disease model; single nucleotide polymorphism






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