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Physiol. Genomics 33: 26-32, 2008. First published January 29, 2008; doi:10.1152/physiolgenomics.00174.2007
1094-8341/08 $8.00
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Received 2 August 2007; accepted in final form 24 January 2008.
Physiological Genomics 33:26-32 (2008)
1094-8341/08 $8.00 © 2008 American Physiological Society

Call For Papers: Computational Modeling for Physiological Systems

Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels

Renhua Li, Karen L. Svenson, Leah Rae B. Donahue, Luanne L. Peters and Gary A. Churchill

The Jackson Laboratory, Bar Harbor, Maine

ABSTRACT

Laboratory inbred mouse strains show a broad range of variation in phenotypes, such as body composition, bone mineral density (BMD), plasma leptin, and insulin-like growth factor I (IGF-I), and thus provide a basis for the study of associations among them. We analyzed these phenotypes in male and female mice from 43 inbred strains fed on a high-fat (30% caloric content) diet and from 30 inbred strains fed on a low-fat (6%) diet. Structural equation modeling of these data reveals that the relationship of body fat content and areal BMD is altered by dietary factors and genotypes. Sex has no net effect on areal BMD, but after accounting for body mass difference females have higher areal BMD. Leptin is affected by relative fat mass and has no net effect on areal BMD. IGF-I has a direct effect on areal BMD.

structural equation models; leptin; insulin-like growth factor I




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G. A. Brockmann, S.-W. Tsaih, C. Neuschl, G. A. Churchill, and R. Li
Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both
Physiol Genomics, January 8, 2009; 36(2): 114 - 126.
[Abstract] [Full Text] [PDF]


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