HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Physiol. Genomics 31: 25-31, 2007. First published May 22, 2007; doi:10.1152/physiolgenomics.00281.2006
1094-8341/07 $8.00

This Article Free upon publication Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: 31/1/25    most recent 00281.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Spielmann, N. Articles by Rankinen, T. Search for Related Content PubMed PubMed Citation Articles by Spielmann, N. Articles by Rankinen, T.

CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study

¹ Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana
² School of Kinesiology, University of Minnesota, Minneapolis, Minnesota
³ Division of Biostatistics and Departments of Genetics and Psychiatry, Washington University School of Medicine, St. Louis, Missouri
⁴ Department of Kinesiology, Indiana University, Bloomington, Indiana

Associations between cholesteryl ester transfer protein (CETP) polymorphisms and high-density lipoprotein cholesterol (HDL-c) levels before and after 20 wk of endurance training were investigated in the HERITAGE Family Study. Plasma HDL-c, HDL₂-c, HDL₃-c, and apolipoprotein (apo)A1 levels were measured, and 13 CETP single nucleotide polymorphisms (SNPs) were genotyped in 265 blacks and 486 whites. Three haplotypes defined by SNPs at the –1337, –971, and –629 sites were strongly associated with baseline HDL-c levels in whites. Both C–1337T and C–629A were associated with baseline HDL-c (P < 0.001) and apoA1 (P < 0.01) when tested separately. However, only C–629A remained significant in a combined model. G–971A was not associated with HDL phenotypes, but showed significant interactions with C–629A (P = 0.002) on baseline traits. Genotype-by-sex interactions were observed at the –629 locus for HDL₃-c (P = 0.004) and apoA1 (P = 0.02) training responses in whites. In women, the –629 A/A homozygotes showed greater increases in HDL₃-c (P = 0.02) and apoA1 (P = 0.02) levels than the other genotypes. Finally, apolipoprotein E (APOE) genotype and the CETP C–629A locus contributed independently and in additive fashion to the HDL traits, explaining 6.0–8.8% of the variance. The CETP –1337T and –629A alleles are associated with higher baseline HDL-c and apoA1 levels. The beneficial effects of endurance training on plasma HDL₃-c and apoA1 levels are evident in white women homozygous for the –629A allele. The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study.

single nucleotide polymorphism; high-density lipoprotein-cholesterol; exercise training; family study