| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina
Substantial variability exists in collateral density and ischemia-induced collateral growth among species. To begin to probe the underlying mechanisms, which are unknown, we characterized two mouse strains with marked differences in both parameters. Immediately after femoral artery ligation, collateral and foot perfusion were lower in BALB/c than C57BL/6 (P < 0.05 here and below), suggesting fewer pre-existing collaterals. This was confirmed with angiography and immunohistochemistry (
35% fewer collaterals in the BALB/c's thigh). Recovery of hindlimb perfusion was attenuated in BALB/c, in association with 54% less collateral remodeling, reduced angiogenesis, greater ischemia, and more impaired hindlimb use. Densities of CD45+ and CD4+ leukocytes around collaterals increased similarly, but TNF-
expression was 50% lower in BALB/c, which may contribute to reduced collateral remodeling. In normal tissues, compared with C57BL/6, BALB/c exhibit an altered arterial branching pattern and, like skeletal muscle above, have 30% fewer collaterals in intestine and, remarkably, almost none in pial circulation, resulting in greatly impaired perfusion after cerebral artery occlusion. Ischemic induction of VEGF-A was attenuated in BALB/c. Analysis of a C57BL/6 x BALB/c recombinant inbred strain dataset identified a quantitative trait locus for VEGF-A mRNA abundance at or near the Vegfa locus that associates with lower expression in BALB/c. This suggests a cis-acting polymorphism in the Vegfa gene in BALB/c could contribute to reduced VEGF-A expression and, in turn, the above deficiencies in this strain. These findings suggest these strains offer a model to investigate genetic determinants of collateral formation and growth in ischemia.
pre-existing collateral network; collateral development and arteriogenesis; cerebral circulation; vascular endothelial growth factor and mouse strains; expression quantitative trait loci
This article has been cited by other articles:
|
|
 |
|
  W. Li, R. Prakash, A. I. Kelly-Cobbs, S. Ogbi, A. Kozak, A. B. El-Remessy, D. A. Schreihofer, S. C. Fagan, and A. Ergul Adaptive Cerebral Neovascularization in a Model of Type 2 Diabetes: Relevance to Focal Cerebral Ischemia Diabetes, January 1, 2010; 59(1): 228 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Keum and D. A. Marchuk A Locus Mapping to Mouse Chromosome 7 Determines Infarct Volume in a Mouse Model of Ischemic Stroke Circ Cardiovasc Genet, December 1, 2009; 2(6): 591 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Nickerson, J. Song, J. K. Meisner, S. Bajikar, C. W. Burke, C. W. Shuptrine, G. K. Owens, T. C. Skalak, and R. J. Price Bone Marrow-Derived Cell-Specific Chemokine (C-C Motif) Receptor-2 Expression is Required for Arteriolar Remodeling Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1794 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Li, J. Liu, M. Michaud, M. L. Schwartz, and J. A. Madri Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal: Modeling the Neurovascular Niche Am. J. Pathol., November 1, 2009; 175(5): 2133 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Waltenberger Limits to Growth of Native Collateral Vessels: Just One Mouse CLIC Away From Unlimited Collateral Perfusion? Circ. Res., July 2, 2009; 105(1): 9 - 11. [Full Text] [PDF]
|
|
|
|
|
|
D. Chalothorn, H. Zhang, J. E. Smith, J. C. Edwards, and J. E. Faber Chloride Intracellular Channel-4 Is a Determinant of Native Collateral Formation in Skeletal Muscle and Brain Circ. Res., July 2, 2009; 105(1): 89 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Belmadani, K. Matrougui, C. Kolz, Y. F. Pung, D. Palen, D. J. Prockop, and W. M. Chilian Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal Cells by Epidermal Growth Factor Arterioscler Thromb Vasc Biol, June 1, 2009; 29(6): 802 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Distasi, J. Case, M. A. Ziegler, M. C. Dinauer, M. C. Yoder, L. S. Haneline, M. C. Dalsing, S. J. Miller, C. A. Labarrere, M. P. Murphy, et al. Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H877 - H886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tian, R. S. Moore, W. E. Phillips, L. Lin, S. Braddy, J. S. Pryor, R. L. Stockstill, M. D. Hughson, and R. D. Manning Jr. NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1858 - R1865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Chilian and Y. F. Pung Vascular Endothelial Growth Factor and the Collateral Circulation: The Story Continues Circ. Res., October 24, 2008; 103(9): 905 - 906. [Full Text] [PDF]
|
|
|
|
|
|
J. A. Clayton, D. Chalothorn, and J. E. Faber Vascular Endothelial Growth Factor-A Specifies Formation of Native Collaterals and Regulates Collateral Growth in Ischemia Circ. Res., October 24, 2008; 103(9): 1027 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cheng, H. Zhang, X. Yang, E. Tzima, K. L. Ewalt, P. Schimmel, and J. E. Faber Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1138 - R1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kinnaird, E. Stabile, S. Zbinden, M.-S. Burnett, and S. E. Epstein Cardiovascular risk factors impair native collateral development and may impair efficacy of therapeutic interventions Cardiovasc Res, May 1, 2008; 78(2): 257 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Isenberg, D. D. Roberts, and W. A. Frazier CD47: A New Target in Cardiovascular Therapy Arterioscler Thromb Vasc Biol, April 1, 2008; 28(4): 615 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Messina Elucidating the Genetic Basis of Peripheral Arterial Disease: Identification of a Quantitative Trait Locus That Determines the Phenotypic Response to Experimental Hindlimb Ischemia Circulation, March 4, 2008; 117(9): 1127 - 1129. [Full Text] [PDF]
|
|
|
|
|
|
A. O. Dokun, S. Keum, S. Hazarika, Y. Li, G. M. Lamonte, F. Wheeler, D. A. Marchuk, and B. H. Annex A Quantitative Trait Locus (LSq-1) on Mouse Chromosome 7 Is Linked to the Absence of Tissue Loss After Surgical Hindlimb Ischemia Circulation, March 4, 2008; 117(9): 1207 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Schaper Prevention of Tissue Death by Killer Cells?: The Role of the Immune System in Arteriogenesis Arterioscler Thromb Vasc Biol, November 1, 2007; 27(11): 2273 - 2274. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
