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Physiol. Genomics 3: 33-38, 2000;
1094-8341/00 $5.00
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Received 15 March 2000; accepted in final form 13 May 2000.
Physiological Genomics 3:33-38 (2000)
1094-8341/00 $5.00 © 2000 American Physiological Society

Blood pressure QTL that differentiate Dahl salt-sensitive and spontaneously hypertensive rats

MICHAEL R. GARRETT , YASSER SAAD , HOWARD DENE and JOHN P. RAPP

Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614-5804

Garrett, Michael R., Yasser Saad, Howard Dene, and John P. Rapp. Blood pressure QTL that differentiate Dahl salt-sensitive and spontaneously hypertensive rats. Physiol Genomics 3: 33–38, 2000.—Our purpose was to define quantitative trait loci (QTL) for blood pressure that differ between two widely used hypertensive rat strains, the Dahl salt-sensitive (S) rat and the spontaneously hypertensive rat (SHR). A genome scan was done on an F2 (S x SHR) population fed 8% NaCl for 4 wk. Three blood pressure QTL were detected, one on each of rat chromosomes (chr) 3, 8, and 9. For the chr 3 QTL the SHR allele increased blood pressure, and for chr 8 and 9 the S allele increased blood pressure. The QTL on chr 9 was exceptionally strong, having a LOD score of 7.3 and accounting for 30% of the phenotypic variance and a difference of 40 mmHg between homozygotes. A review of the literature in conjunction with the present data suggests that S and SHR are not different for the previously described prominent blood pressure QTL on chr 1, 2, 10, and 13. QTL for body weight on chr 4, 12, 18, and 20, each with an effect of about 30 g, were incidentally observed.

high blood pressure; body weight; heart weight; SHR; Dahl S rats




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