HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplement Materials All Versions of this Article: 27/2/122    most recent 00068.2006v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Rikke, B. A. Articles by Johnson, T. E. Search for Related Content PubMed PubMed Citation Articles by Rikke, B. A. Articles by Johnson, T. E.

Murine weight loss exhibits significant genetic variation during dietary restriction

¹ Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado
² Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama
³ Department of Integrative Physiology, University of Colorado, Boulder, Colorado

We present genetic analyses of murine weight loss during dietary restriction (DR) for females eating 60% ad libitum (AL). We examined 5 cohorts across 81 different strains (22 strains tested twice) that included the LXS and LSXSS recombinant inbred strains, the LXS parental strains ILS and ISS, and the classical inbreds 129S6, A, BALB/c, C57BL/6, C3H, and DBA. Weight loss exhibited highly significant genetic variation, with DR body weights ranging from 60 to 85% of AL body weight. This variation was not explained by the strain differences in absolute food intake, feces calorie content, motor activity, or AL body fat. Heritability was 40–50%, and several provisional quantitative trait loci were mapped. This variation can be used to test whether weight loss correlates with the health benefits of DR, independently of the reduction in calories. The genetic variation also implies the existence of genes that would be novel therapeutic targets, distinct from genes affecting AL body weight or body fat, for enhancing (or mitigating) weight loss during food restriction.

body weight; caloric restriction; dieting; energy restriction; food restriction; genetics; quantitative trait loci; weight control; weight modulation

This article has been cited by other articles:

				B. A. Rikke and T. E. Johnson Physiological genetics of dietary restriction: uncoupling the body temperature and body weight responses Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1522 - R1527. [Abstract] [Full Text] [PDF]