HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 22/3/319    most recent 00073.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Hägg, U. Articles by Gan, L.-m. Search for Related Content PubMed PubMed Citation Articles by Hägg, U. Articles by Gan, L.-m.

Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential role of heat shock proteins

¹ Department of Physiology, Institute of Physiology and Pharmacology, Göteborg University;
² Department of Clinical Physiology, Cardiovascular Institute, Sahlgrenska University Hospital;
³ Institute of Stress Medicine;
⁴ Department of Internal Medicine, Research Centre for Endocrinology and Metabolism, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden

Physical exercise is considered to be beneficial for cardiovascular health. Nevertheless, the underlying specific molecular mechanisms still remain unexplored. In this study, we aimed to investigate the effects of voluntary exercise on vascular mechanical properties and gene regulation patterns in spontaneously hypertensive rats. By using ultrasound biomicroscopy in an ex vivo perfusion chamber, we studied the distensibility of the thoracic aorta. Furthermore, exercise-induced gene regulation was studied in aortae, using microarray analysis and validated with real-time PCR. We found that distensibility was significantly improved in aortas from exercising compared with control rats (P < 0.0001). Exercising rats demonstrated a striking pattern of coordinated downregulation of genes belonging to the heat shock protein family. In conclusion, voluntary exercise leads to improved vessel wall distensibility and reduced gene expression of heat shock protein 60 and 70, which may indicate decreased oxidative stress in the aortic vascular wall.

microarray; ultrasound biomicroscopy; oxidative stress

This article has been cited by other articles:

				M. E. Johansson, I. J. Andersson, C. Alexanderson, O. Skott, A. Holmang, and G. Bergstrom Hyperinsulinemic rats are normotensive but sensitized to angiotensin II Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1240 - R1247. [Abstract] [Full Text] [PDF]

				N. Nitescu, E. Grimberg, S.-E. Ricksten, N. Marcussen, H. Nordlinder, and G. Guron Effects of thrombin inhibition with melagatran on renal hemodynamics and function and liver integrity during early endotoxemia Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1117 - R1124. [Abstract] [Full Text] [PDF]

				M. Liang and B. Ventura Physiological genomics in PG and beyond: July to September 2005 Physiol Genomics, October 17, 2005; 23(2): 119 - 124. [Full Text] [PDF]