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Physiol. Genomics 22: 76-85, 2005. First published April 26, 2005; doi:10.1152/physiolgenomics.00243.2004
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Influence of genetic background on daily running-wheel activity differs with aging

¹ Department of Kinesiology, University of North Carolina-Charlotte, Charlotte
² Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Durham, North Carolina

In humans, physical activity declines with age. We tested the hypothesis that genetic background and age interact to determine daily wheel-running physical activity patterns in mice. Five female mice from ten inbred strains (A/J, AKR/J, Balb/cJ, CBA/J, C3H/HeJ, C3Heb/FeJ, C57Bl/6J, C57L/J, DBA/2J, and SWR/J) were studied for 26 wk starting at 10 wk of age. All mice were housed in separate cages, each with a running wheel and magnetic sensor. Throughout the 26-wk period, age-related change in daily duration (P < 0.0001), daily distance (P < 0.0001), and average velocity (P = 0.0003) differed between the inbred strains. Unlike the other strains, SWR/J mice increased their running-wheel activity throughout the 6-mo time period. Broad-sense heritability estimations for the strains across the 26-wk period ranged between 0.410 and 0.855 for the three physical activity phenotypes. Furthermore, the broad-sense heritability estimates for daily running-wheel distance differed across time and suggested an interaction between genetic background and age on physical activity in these inbred mice.

average daily activity; body weight; broad-sense heritability; inbred mice

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