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Physiol. Genomics 2: 93-100, 2000;
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Received 3 December 1999; accepted in final form 12 February 2000.
Physiological Genomics 2:93-100 (2000)
1094-8341/00 $5.00 © 2000 American Physiological Society

Gene expression profile in mouse myocardium after ischemia

DEBORAH LYN, XIAOWEI LIU, NICOLE A. BENNETT and NERIMIAH L. EMMETT

Departments of Biochemistry and Physiology, and the Cardiovascular Institute, Morehouse School of Medicine, Atlanta, Georgia 30310

Lyn, Deborah, Xiaowei Liu, Nicole A. Bennett, and Nerimiah L. Emmett. Gene expression profile in mouse myocardium after ischemia. Physiol Genomics 2: 93–100, 2000.—This study was designed to elaborate a molecular profile of expressed genes during ischemic injury to the mouse heart after surgical constriction of the left coronary artery without reperfusion. A mouse cDNA array containing 588 known genes was used to compare gene expression in heart RNA after 24-h ischemia with control tissue. Alterations in gene expression on the array were supported by relative reverse transcription-polymerase chain reaction analysis after timed periods of ischemia. Decreased levels of the cell cycle regulator p18ink4 and the oxidative responsive gene glutathione S-transferase were accompanied by an upregulation of the genes associated with cardiac muscle development, {alpha}-myosin heavy chain and fetal myosin alkali light chain. Other stress responses elicited by cardiac injury included an induction of Egr-1 and Egr-3 transcription factors, as well as the apoptotic regulator Bax. Altogether, these findings indicate that expression of genes associated with a fetal transcription program may be involved with the post ischemic remodeling process in heart ventricles.

complementary deoxyribonucleic acid array; coronary artery occlusion; myosin; p18ink4; transcription factors




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