HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 17/3/326    most recent 00161.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Huang, Q.-Y. Articles by Deng, H.-W. Search for Related Content PubMed PubMed Citation Articles by Huang, Q.-Y. Articles by Deng, H.-W.

Genome scan for QTLs underlying bone size variation at 10 refined skeletal sites: genetic heterogeneity and the significance of phenotype refinement

¹ Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131
² Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131
³ Center for Medical Informatics, School of Medicine, Yale University, New Haven, Connecticut 06520-8009
⁴ Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, ChangSha, Hunan, 410081, China

To identify quantitative trait loci (QTLs) underlying variation in bone size, we conducted a whole-genome linkage scan in 53 pedigrees with 630 subjects using 380 microsatellite markers. Lumbar area 1, 2, 3, and 4 at the spine, femoral neck, trochanter, intertrochanter areas at the hip, ultradistal, mid-distal, and one-third distal areas at the wrist were measured by dual-energy X-ray absorptiometry (DXA), and adjusted for age, height, weight, and sex. Two-point and multipoint linkage analyses were performed for skeletal bone size at each site and their composite measurements using the SOLAR package. Two chromosomal regions (1q22 and 10q21) were identified with significant evidence of linkage (LOD > 4.32) to one-third distal area, and three were identified with suggestive evidence of linkage (LOD > 2.93) to bone size in one skeletal site. Our results indicated that the low power of QTLs mapping for composite phenotypic measurements may result from genetic heterogeneity of complex traits.

osteoporosis; linkage; quantitative trait loci

This article has been cited by other articles:

				J. P. Kenney-Hunt, B. Wang, E. A. Norgard, G. Fawcett, D. Falk, L. S. Pletscher, J. P. Jarvis, C. Roseman, J. Wolf, and J. M. Cheverud Pleiotropic Patterns of Quantitative Trait Loci for 70 Murine Skeletal Traits Genetics, April 1, 2008; 178(4): 2275 - 2288. [Abstract] [Full Text] [PDF]