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1 Institut fuer Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe
2 Institut fuer Pathologie, Universitaet Bonn, 53127 Bonn, Germany
3 Institut fuer Angewandte Informatik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
We have monitored global changes in gene expression in mouse liver in response to fasting and sugar-fed conditions using high-density microarrays. From 
20,000 different genes, the significantly regulated ones were grouped into specific signaling and metabolic pathways. Striking changes in lipid signaling cascade, insulin and dehydroepiandrosterone (DHEA) hormonal pathways, urea cycle and S-adenosylmethionine-based methyl transfer systems, and cell apoptosis regulators were observed. Since these pathways have been implicated to play a role in the aging process, and since we observe significant overlap of genes regulated upon starvation with those regulated upon caloric restriction, our analysis suggests that starvation may elicit a stress response that is also elicited during caloric restriction. Therefore, many of the signaling and metabolic components regulated during fasting may be the same as those which mediate caloric restriction-dependent life-span extension.
microarray analysis; nutrient response; caloric restriction; metabolic signaling; aging/longevity
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