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Physiol. Genomics 16: 329-333, 2004. First published December 9, 2003; doi:10.1152/physiolgenomics.00162.2003
1094-8341/04 $5.00
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Received 25 September 2003; accepted in final form 6 December 2003.
Physiological Genomics 16:329-333 (2004)
1094-8341/04 $5.00 © 2004 American Physiological Society

X-linked loci influence spatial navigation performance in Dahl rats

Nelson Ruiz-Opazo1,3 and John Tonkiss2

1 Section of Molecular Medicine, Department of Medicine
2 Center for Behavioral Development and Mental Retardation, Boston University School of Medicine, Boston, Massachusetts 02118

Elucidation of natural genetic variations underlying strain or individual differences in cognitive function has remained elusive. Here we report the identification of two genetic loci that influence spatial navigation in Dahl rats. In the Morris water maze test, Dahl R rats exhibited efficient spatial navigation, whereas Dahl S rats displayed poor spatial navigation (accuracy). Analysis of F1 male progeny of reciprocal crosses between Dahl S and Dahl R strains implicated the X chromosome with the impairment in spatial navigation observed in Dahl S rats. Quantitative trait locus (QTL) analysis of an (RXS) F2 male population phenotyped for spatial navigation detected two QTLs on chromosome X influencing spatial navigation performance. One QTL (Nav-1, centered at DXRat21, significant for linkage) influenced acquisition performance without affecting spatial accuracy performance; and the second QTL (Nav-2, centered at DXRat25, significant for linkage) affected spatial accuracy performance with no detectable effect on acquisition performance. Our results demonstrate X linkage of spatial navigation performance in Dahl rats and provide evidence for the existence of independent genetic determinants for defined behavioral components of spatial navigation.

genetics; quantitative trait locus; spatial navigation; Morris water maze




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N. Ruiz-Opazo and J. Tonkiss
Genome-wide scan for quantitative trait loci influencing spatial navigation and social recognition memory in Dahl rats
Physiol Genomics, September 14, 2006; 26(2): 145 - 151.
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