HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (22) Citing Articles via Google Scholar Google Scholar Articles by Phoon, C. K. L. Articles by Turnbull, D. H. Search for Related Content PubMed PubMed Citation Articles by Phoon, C. K. L. Articles by Turnbull, D. H.

Review

Ultrasound biomicroscopy-Doppler in mouse cardiovascular development¹

¹ Skirball Institute of Biomolecular Medicine
² Pediatric Cardiology Program, Department of Pediatrics
³ Departments of Radiology and Pathology, New York University School of Medicine, New York, New York 10016

The ability to modify the mouse genome has yielded new insights into the genetic control of mammalian cardiovascular development. However, it is far less understood how genetic factors and their consequent structural changes alter cardiovascular function, a void largely due to the lack of effective noninvasive techniques to assess function in the developing mouse cardiovascular system. In this review, we discuss the recent advances in ultrasound biomicroscopy (UBM)-Doppler echocardiography for analyzing cardiovascular function in the embryonic mouse in utero. "Cardiovascular function" encompasses broad aspects of physiology, including systolic and diastolic cardiac function, distribution of blood flow among various embryonic vascular beds, and vascular bed properties (impedance). A wide range of physiological measurements is possible using UBM-Doppler, but it is clear that the limitations of any single measurement warrant a multi-parameter approach to characterizing cardiovascular function. We further discuss the prospects for UBM-Doppler analysis of alternative vertebrate systems increasingly studied in developmental biology. The ability to correlate cardiovascular physiological phenotypes with their corresponding genotypes should lead to the elucidation of mechanisms underlying normal development, as well as embryonic disease and death.

cardiac morphogenesis; echocardiography; embryogenesis

This article has been cited by other articles:

				A. Nomura-Kitabayashi, C. K. L. Phoon, S. Kishigami, J. Rosenthal, Y. Yamauchi, K. Abe, K.-i. Yamamura, R. Samtani, C. W. Lo, and Y. Mishina Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1617 - H1628. [Abstract] [Full Text] [PDF]

				J. Mu, D. Qu, A. Bartczak, M. J. Phillips, J. Manuel, W. He, C. Koscik, M. Mendicino, L. Zhang, D. A. Clark, et al. Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice Physiol Genomics, September 11, 2007; 31(1): 53 - 62. [Abstract] [Full Text] [PDF]

				J. Mu and S. L. Adamson Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1421 - H1428. [Abstract] [Full Text] [PDF]

				Y. Shen, L. Leatherbury, J. Rosenthal, Q. Yu, M. A. Pappas, A. Wessels, J. Lucas, B. Siegfried, B. Chatterjee, K. Svenson, et al. Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital cardiac and extracardiac defects Physiol Genomics, December 14, 2005; 24(1): 23 - 36. [Abstract] [Full Text] [PDF]

				B. B. Keller Developmental structure-function insights from Tbx5del/+ mouse model of Holt-Oram syndrome Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H975 - H976. [Full Text] [PDF]

				Y.-Q. Zhou, Y. Zhu, J. Bishop, L. Davidson, R. M. Henkelman, B. G. Bruneau, and F. S. Foster Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H992 - H1001. [Abstract] [Full Text] [PDF]

				C. K.L. Phoon, R. P. Ji, O. Aristizabal, D. M. Worrad, B. Zhou, H. S. Baldwin, and D. H. Turnbull Embryonic Heart Failure in NFATc1-/- Mice: Novel Mechanistic Insights From In Utero Ultrasound Biomicroscopy Circ. Res., July 9, 2004; 95(1): 92 - 99. [Abstract] [Full Text] [PDF]