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Physiol. Genomics 13: 197-205, 2003; doi:10.1152/physiolgenomics.00164.2002
1094-8341/03 $5.00
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Received 20 November 2002; accepted in final form 12 February 2003.
Physiological Genomics 13:197-205 (2003)
1094-8341/03 $5.00 © 2003 American Physiological Society

Review

Evaluation and applications of radiotelemetry in small laboratory animals1

Klaas Kramer1 and Lewis B. Kinter2

1 Department of Safety and Environmental Affairs, Free University, DVM, 1081 BT Amsterdam, The Netherlands
2 Safety Assessment, AstraZeneca Pharmaceuticals, Wilmington, Delaware, 19850

Radiotelemetry is the "state of the art" for monitoring physiological functions in awake and freely moving laboratory animals, while minimizing stress artifacts. For researchers, especially those in the fields of pharmacology and toxicology, the technique provides a valuable tool for defining the physiological and pathophysiological consequences derived from advances molecular, cellular, and tissue biology and in predicting the effectiveness and safety of new compounds in humans. There is ample evidence that radiotelemetry systems for measuring physiological functions has been sufficiently validated. Today, the technology is an important tool for collection of a growing number of physiological parameters, for contributing to animal welfare (reduction and refinement alternatives), and for reducing overall animal research costs.

rat; mouse; animal welfare; research costs




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