| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Biostatistics, Harvard University, Boston 02115
2 Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021
3 Department of Genetics, Washington University School of Medicine, St. Louis 63110
4 Department of Internal Medicine, Division of Dermatology, Baylor University Medical Center, Dallas, Texas 75246
5 Department of Statistics, Harvard University, Cambridge, Massachusetts 02138
6 Departments of Pediatrics and Medicine, Washington University School of Medicine, St. Louis, Missouri 63110
A global picture of gene expression in the common immune-mediated skin disease, psoriasis, was obtained by interrogating the full set of Affymetrix GeneChips with psoriatic and control skin samples. We identified 1,338 genes with potential roles in psoriasis pathogenesis/maintenance and revealed many perturbed biological processes. A novel method for identifying transcription factor binding sites was also developed and applied to this dataset. Many of the identified sites are known to be involved in immune response and proliferation. An in-depth study of immune system genes revealed the presence of many regulating cytokines and chemokines within involved skin, and markers of dendritic cell (DC) activation in uninvolved skin. The combination of many CCR7+ T cells, DCs, and regulating chemokines in psoriatic lesions, together with the detection of DC activation markers in nonlesional skin, strongly suggests that the spatial organization of T cells and DCs could sustain chronic T-cell activation and persistence within focal skin regions.
immune signaling; promoter analysis; chemokines; gene expression
This article has been cited by other articles:
|
|
 |
|
  L. C. Zaba, I. Cardinale, P. Gilleaudeau, M. Sullivan-Whalen, M. Suarez-Farinas, J. Fuentes-Duculan, I. Novitskaya, A. Khatcherian, M. J. Bluth, M. A. Lowes, et al. Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses J. Exp. Med., December 24, 2007; 204(13): 3183 - 3194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Arakura, S. Hida, E. Ichikawa, C. Yajima, S. Nakajima, T. Saida, and S. Taki Genetic Control Directed toward Spontaneous IFN-{alpha}/IFN-beta Responses and Downstream IFN-{gamma} Expression Influences the Pathogenesis of a Murine Psoriasis-Like Skin Disease J. Immunol., September 1, 2007; 179(5): 3249 - 3257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yan, M. R. Mehan, Y. Huang, M. S. Waterman, P. S. Yu, and X. J. Zhou A graph-based approach to systematically reconstruct human transcriptional regulatory modules Bioinformatics, July 1, 2007; 23(13): i577 - i586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Mee, C. M. Johnson, N. Morar, F. Burslem, and R. W. Groves The Psoriatic Transcriptome Closely Resembles That Induced by Interleukin-1 in Cultured Keratinocytes: Dominance of Innate Immune Responses in Psoriasis Am. J. Pathol., July 1, 2007; 171(1): 32 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Sa, P. A. Valdez, J. Wu, K. Jung, F. Zhong, L. Hall, I. Kasman, J. Winer, Z. Modrusan, D. M. Danilenko, et al. The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis J. Immunol., February 15, 2007; 178(4): 2229 - 2240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cumberbatch, M. Singh, R. J. Dearman, H. S. Young, I. Kimber, and C. E.M. Griffiths Impaired Langerhans cell migration in psoriasis J. Exp. Med., April 17, 2006; 203(4): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Gottlieb, F. Chamian, S. Masud, I. Cardinale, M. V. Abello, M. A. Lowes, F. Chen, M. Magliocco, and J. G. Krueger TNF Inhibition Rapidly Down-Regulates Multiple Proinflammatory Pathways in Psoriasis Plaques J. Immunol., August 15, 2005; 175(4): 2721 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J G Krueger and A Bowcock Psoriasis pathophysiology: current concepts of pathogenesis Ann Rheum Dis, March 1, 2005; 64(suppl_2): ii30 - ii36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T Elder Psoriasis clinical registries, genetics, and genomics Ann Rheum Dis, March 1, 2005; 64(suppl_2): ii106 - ii107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Chamian, M. A. Lowes, S.-L. Lin, E. Lee, T. Kikuchi, P. Gilleaudeau, M. Sullivan-Whalen, I. Cardinale, A. Khatcherian, I. Novitskaya, et al. Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris PNAS, February 8, 2005; 102(6): 2075 - 2080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bowcock and W. O.C.M. Cookson The genetics of psoriasis, psoriatic arthritis and atopic dermatitis Hum. Mol. Genet., April 1, 2004; 13(90001): R43 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lee, W. L. Trepicchio, J. L. Oestreicher, D. Pittman, F. Wang, F. Chamian, M. Dhodapkar, and J. G. Krueger Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris J. Exp. Med., January 5, 2004; 199(1): 125 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bomprezzi, M. Ringner, S. Kim, M. L. Bittner, J. Khan, Y. Chen, A. Elkahloun, A. Yu, B. Bielekova, P. S. Meltzer, et al. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease Hum. Mol. Genet., September 1, 2003; 12(17): 2191 - 2199. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
