Physiol. Genomics Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Genomics 11: 263-272, 2002. First published October 22, 2002; doi:10.1152/physiolgenomics.00110.2002
1094-8341/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow All Versions of this Article:
11/3/263    most recent
00110.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (26)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paoni, N. F.
Right arrow Articles by Powell-Braxton, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paoni, N. F.
Right arrow Articles by Powell-Braxton, L.
Received 21 August 2002; accepted in final form 9 October 2002.
Physiological Genomics 11:263-272 (2002)
1094-8341/02 $5.00 © 2002 American Physiological Society

Time course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice

Nicholas F. Paoni 1, Franklin Peale 2, Fay Wang 1, Carol Errett-Baroncini 1, Hope Steinmetz 1, Karen Toy 3, Wei Bai 2, P. Mickey Williams 3, Stuart Bunting 1, Mary E. Gerritsen 1 and Lyn Powell-Braxton 1

1 Department of Cardiovascular Research, South San Francisco, California 94080
2 Department of Pathology, South San Francisco, California 94080
3 Bioanalytical Technology, Genentech, Inc., South San Francisco, California 94080

DNA microarrays were used to measure the time course of gene expression during skeletal muscle damage and regeneration in mice following femoral artery ligation (FAL). We found 1,289 known sequences were differentially expressed between the FAL and control groups. Gene expression peaked on day 3, and the functional cluster "inflammation" contained the greatest number of genes. Muscle function was depressed for 3 days postligation, but returned to normal by day 7. Decreased muscle function was accompanied by reduced expression of genes involved in mitochondrial energy production, muscle contraction, and calcium handling. The induction of MyoD on day 1 denoted the beginning of muscle regeneration and was followed by the reemergence of the embryonic forms of muscle contractile proteins, which peaked at day 7. Transcriptional analysis indicated that the ischemic skeletal muscle may transition through a functional adaptation stage with recovery of contractile force prior to full regeneration. Several members of the insulin-like growth factor axis were coordinately induced in a time frame consistent with their playing a role in the regenerative process.

expression profiling; insulin-like growth factor; peripheral artery disease; muscle regeneration; inflammation




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
B. J. Capoccia, A. D. Gregory, and D. C. Link
Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion
J. Leukoc. Biol., September 1, 2008; 84(3): 760 - 768.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Z. Behm, B. A. Kaufmann, C. Carr, M. Lankford, J. M. Sanders, C. E. Rose, S. Kaul, and J. R. Lindner
Molecular Imaging of Endothelial Vascular Cell Adhesion Molecule-1 Expression and Inflammatory Cell Recruitment During Vasculogenesis and Ischemia-Mediated Arteriogenesis
Circulation, June 3, 2008; 117(22): 2902 - 2911.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
V. van Weel, L. Seghers, M. R. de Vries, E. J. Kuiper, R. O. Schlingemann, I. M. Bajema, J. H.N. Lindeman, P. M. Delis-van Diemen, V. W.M. van Hinsbergh, J. H. van Bockel, et al.
Expression of Vascular Endothelial Growth Factor, Stromal Cell-Derived Factor-1, and CXCR4 in Human Limb Muscle With Acute and Chronic Ischemia
Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1426 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
A. M. Heemskerk, G. J. Strijkers, M. R. Drost, G. S. van Bochove, and K. Nicolay
Skeletal Muscle Degeneration and Regeneration after Femoral Artery Ligation in Mice: Monitoring with Diffusion MR Imaging
Radiology, May 1, 2007; 243(2): 413 - 421.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. Pescatori, A. Broccolini, C. Minetti, E. Bertini, C. Bruno, A. D'amico, C. Bernardini, M. Mirabella, G. Silvestri, V. Giglio, et al.
Gene expression profiling in the early phases of DMD: a constant molecular signature characterizes DMD muscle from early postnatal life throughout disease progression
FASEB J, April 1, 2007; 21(4): 1210 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Sadasivam, R. Willmann, S. Lin, S. Erb-Vogtli, X. C. Kong, M. A. Ruegg, and C. Fuhrer
Src-Family Kinases Stabilize the Neuromuscular Synapse In Vivo via Protein Interactions, Phosphorylation, and Cytoskeletal Linkage of Acetylcholine Receptors
J. Neurosci., November 9, 2005; 25(45): 10479 - 10493.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
T. Y. Kostrominova, D. E. Dow, R. G. Dennis, R. A. Miller, and J. A. Faulkner
Comparison of gene expression of 2-mo denervated, 2-mo stimulated-denervated, and control rat skeletal muscles
Physiol Genomics, July 14, 2005; 22(2): 227 - 243.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Fluck, S. Schmutz, M. Wittwer, H. Hoppeler, and D. Desplanches
Transcriptional reprogramming during reloading of atrophied rat soleus muscle
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R4 - R14.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. E. Spangenburg
SOCS-3 Induces Myoblast Differentiation
J. Biol. Chem., March 18, 2005; 280(11): 10749 - 10758.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Scholz and W. Schaper
Preconditioning of arteriogenesis
Cardiovasc Res, February 1, 2005; 65(2): 513 - 523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. I. Lewis, M. Fournier, X. Da, H. Li, Z. Mosenifar, R. J. McKenna Jr, and A. H. Cohen
Short-term Influences of Lung Volume Reduction Surgery on the Diaphragm in Emphysematous Hamsters
Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 753 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
N. F. Paoni, M. W. Feldman, L. S. Gutierrez, V. A. Ploplis, and F. J. Castellino
Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse
Physiol Genomics, November 11, 2003; 15(3): 228 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Hirata, S. Masuda, T. Tamura, K. Kai, K. Ojima, A. Fukase, K. Motoyoshi, K. Kamakura, Y. Miyagoe-Suzuki, and S.'i. Takeda
Expression Profiling of Cytokines and Related Genes in Regenerating Skeletal Muscle after Cardiotoxin Injection: A Role for Osteopontin
Am. J. Pathol., July 1, 2003; 163(1): 203 - 215.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online