Physiol. Genomics AJP: Lung Cellular and Molecular Physiology
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Physiol. Genomics 11: 179-182, 2002; doi:10.1152/physiolgenomics.00063.2002
1094-8341/02 $5.00
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Received 24 May 2002; accepted in final form 11 October 2002.
Physiological Genomics 11:179-182 (2002)
1094-8341/02 $5.00 © 2002 American Physiological Society

Perspective

What can cardiovascular gene transfer learn from genomics: and vice versa?

Tae Ho Kim2, Kimberly A. Skelding1, Elizabeth G. Nabel3 and Robert D. Simari1

1 Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology, Molecular Medicine Program, Mayo Clinic and Foundation, Rochester, Minnesota 55905
2 Division of Cardiovascular Disease, Department of Internal Medicine, Chung-Ang University Hospital, Seoul 140-757, Korea
3 National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892

The field of gene transfer has developed in an era of expanding biomedical knowledge. The potential for gene transfer to treat cardiovascular disease is great, yet identified and unidentified barriers remain. Gene transfer and its ultimate application, gene therapy, require extensive details of not only the mechanism of disease but the biological implications of the vectors used to deliver the therapeutic genes as well. Many of these details are becoming available via the study of genomics. Genomics, the study of complete genetic sequences, holds the potential for enabling and amplifying the therapeutic hopes for gene transfer. Identification of new therapeutic genes, new regulatory sequences, and establishing the patterns of gene expression from tissues exposed to vectors and transgenes will rapidly advance the application of gene transfer. Finally, there are historical and ongoing lessons learned from the development of gene transfer that may be applicable to the challenging field of genomics and may enable its future success.

gene therapy; vectors




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