HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Halfon, M. S. Articles by Michelson, A. M. Search for Related Content PubMed PubMed Citation Articles by Halfon, M. S. Articles by Michelson, A. M.

Invited Review

Exploring genetic regulatory networks in metazoan development: methods and models^*

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Howard Hughes Medical Institute, Boston, Massachusetts 02115

One of the foremost challenges of 21st century biological research will be to decipher the complex genetic regulatory networks responsible for embryonic development. The recent explosion of whole genome sequence data and of genome-wide transcriptional profiling methods, such as microarrays, coupled with the development of sophisticated computational tools for exploiting and analyzing genomic data, provide a significant starting point for regulatory network analysis. In this article we review some of the main methodological issues surrounding genome annotation, transcriptional profiling, and computational prediction of cis-regulatory elements and discuss how the power of model genetic organisms can be used to experimentally verify and extend the results of genomic research.

genomics; cis-regulation; microarrays; computational biology

This article has been cited by other articles:

				I. Yanai, H. Benjamin, M. Shmoish, V. Chalifa-Caspi, M. Shklar, R. Ophir, A. Bar-Even, S. Horn-Saban, M. Safran, E. Domany, et al. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification Bioinformatics, March 1, 2005; 21(5): 650 - 659. [Abstract] [Full Text] [PDF]

				W. Thompson, M. J. Palumbo, W. W. Wasserman, J. S. Liu, and C. E. Lawrence Decoding Human Regulatory Circuits Genome Res., October 1, 2004; 14(10a): 1967 - 1974. [Abstract] [Full Text] [PDF]

				M. Liang, A. W. Cowley Jr, and A. S. Greene High throughput gene expression profiling: a molecular approach to integrative physiology J. Physiol., January 1, 2004; 554(1): 22 - 30. [Abstract] [Full Text] [PDF]