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Physiol. Genomics 10: 71-77, 2002. First published June 11, 2002; doi:10.1152/physiolgenomics.00050.2002
1094-8341/02 $5.00
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Received 29 April 2002; accepted in final form 10 June 2002.
Physiological Genomics 10:71-77 (2002)
1094-8341/02 $5.00 © 2002 American Physiological Society

Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism

Rainer Rauramaa1,2, Raimo Kuhanen1, Timo A. Lakka1,3, Sari B. Väisänen1,4, Pirjo Halonen5, Markku Alén6, Tuomo Rankinen1,3 and Claude Bouchard3

1 Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, 70100 Kuopio
2 Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, 70211 Kuopio
3 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808-4124
4 Department of Clinical Chemistry, Kuopio University Hospital, 70211 Kuopio
5 Computing Centre, University of Kuopio, 70211 Kuopio
6 Peurunka Rehabilitation Centre, 41340 Laukaa, Finland

We investigated the role of the angiotensinogen (AGT) gene M235T polymorphism in determining blood pressure (BP) response to moderate intensity exercise in a 6-yr randomized controlled trial in 140 middle-aged men. Sitting, supine, and standing blood pressures were measured annually. Of the randomized men, 86% participated in the trial for 6 yr. Submaximal cardiorespiratory fitness increased by 16% in the exercise group. In the M homozygotes, sitting systolic BP decreased by 1.0 mmHg in the exercise but increased by 14.6 mmHg in the reference group (P = 0.007 for net effect). Sitting and supine diastolic BP decreased by 6.2 and 3.3 mmHg in the exercise but increased by 2.8 and 3.2 mmHg in the reference group (P = 0.026 and 0.024 for net effects), respectively. Regular moderate intensity exercise attenuates aging-related increase in systolic BP and decreases diastolic BP among the M homozygotes of the AGT gene M235T polymorphism.

physical activity; DNA polymorphism; randomized controlled trial




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