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Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women

¹ Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
² Department of Human Kinetics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201
³ Department of Kinesiology, University of Maryland, College Park 20742
⁴ Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261
⁵ Department of Entomology, University of Maryland, College Park 20742
⁶ Biometrics Program, Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742

We sought to determine whether the M235T angiotensinogen (AGT) polymorphism, either interacting with habitual physical activity (PA) levels or independently, was associated with cardiovascular (CV) hemodynamics during maximal and submaximal exercise. Sixty-one healthy postmenopausal women (16 sedentary, 21 physically active, and 24 endurance athletes) had heart rate (HR), blood pressure (BP), cardiac output, stroke volume (SV), total peripheral resistance (TPR), and arteriovenous O₂ difference (a-vDO₂) assessed during 40, 60, 80, and 100% of VO_{2 max} treadmill exercise. VO_{2 max} did not differ among AGT genotype groups; however, maximal HR was 14 beats/min higher in AGT TT than MM genotype women (P < 0.05). AGT TT genotype women also had 19 beats/min higher HR during 100% VO_{2 max} exercise than AGT MM genotype women (P = 0.008). AGT genotype also interacted with habitual PA levels to associate with systolic BP and a-vDO₂ during 100% VO_{2 max} exercise (both P < 0.01). AGT TT genotype women had 11 beats/min higher HR during submaximal exercise than MM genotype women (P < 0.05). AGT genotype interacted with habitual PA levels to associate with systolic BP during submaximal exercise (P = 0.009). AGT genotype, independently or interacting with habitual PA levels, did not associate significantly with diastolic BP, cardiac output, SV, or TPR during maximal or submaximal exercise. Thus this common genetic variant in the renin-angiotensin system appears to associate, both interactively with habitual PA levels and independently, with HR, systolic BP, and a-vDO₂ responses to maximal and submaximal exercise in postmenopausal women.

heart rate; blood pressure; cardiac output; stroke volume; genetics

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				S. D. McCole, A. R. Shuldiner, M. D. Brown, G. E. Moore, R. E. Ferrell, K. R. Wilund, A. Huberty, L. W. Douglass, and J. M. Hagberg {beta}2- and {beta}3-Adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women J Appl Physiol, February 1, 2004; 96(2): 526 - 530. [Abstract] [Full Text] [PDF]

				L. A. Sonna, S. B. Glueck, and X. Jeunemaitre Exercise, genetics, and blood pressure: Focus on "Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism" and on "Angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopausal women" Physiol Genomics, August 14, 2002; 10(2): 45 - 47. [Full Text] [PDF]