HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 10/1/21    most recent 00018.2002v2 00018.2002v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (20) Citing Articles via Google Scholar Google Scholar Articles by Leamy, L. J. Articles by Cheverud, J. M. Search for Related Content PubMed PubMed Citation Articles by Leamy, L. J. Articles by Cheverud, J. M.

Pleiotropy of quantitative trait loci for organ weights and limb bone lengths in mice

¹ Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223
² Department of Animal Science, University of Nebraska, Lincoln, Nebraska 68583
³ Department of Animal Science, North Carolina State University, Raleigh, North Carolina 27695
⁴ Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110

We investigated the genetic basis of several limb bone lengths and weights of organs in mice produced from a cross of the F₁ between CAST/Ei (wild strain) and M16i (selected for rapid growth rate) back to M16i. From previous correlation studies, we hypothesized that quantitative trait loci (QTLs) would exhibit greater pleiotropy within than between the limb length and organ weight character sets. Using interval mapping procedures and significance testing at the chromosome-wise level, we discovered 14 putative QTLs affecting weight of the liver, spleen, heart, and/or kidney, 9 of which affected more than one organ; and 12 QTLs for limb lengths, all of which affected the length of two or more of the limb bones in these mice. As was hypothesized, most QTLs affected either organ weights or limb lengths independently of each other, although five QTLs were found that affected both sets of characters. The direction of the effect of these QTLs was almost always consistent within and between characters, with little evidence for antagonistic pleiotropy.

interval mapping procedures; antagonistic pleiotropy; modularity

This article has been cited by other articles:

				J. Flint and T. F.C. Mackay Genetic architecture of quantitative traits in mice, flies, and humans Genome Res., May 1, 2009; 19(5): 723 - 733. [Abstract] [Full Text] [PDF]

				J. P. Kenney-Hunt, B. Wang, E. A. Norgard, G. Fawcett, D. Falk, L. S. Pletscher, J. P. Jarvis, C. Roseman, J. Wolf, and J. M. Cheverud Pleiotropic Patterns of Quantitative Trait Loci for 70 Murine Skeletal Traits Genetics, April 1, 2008; 178(4): 2275 - 2288. [Abstract] [Full Text] [PDF]

				H. M. Kang, N. A. Zaitlen, C. M. Wade, A. Kirby, D. Heckerman, M. J. Daly, and E. Eskin Efficient Control of Population Structure in Model Organism Association Mapping Genetics, March 1, 2008; 178(3): 1709 - 1723. [Abstract] [Full Text] [PDF]

				J. T. Lightfoot, M. J. Turner, D. Pomp, S. R. Kleeberger, and L. J. Leamy Quantitative trait loci for physical activity traits in mice Physiol Genomics, February 19, 2008; 32(3): 401 - 408. [Abstract] [Full Text] [PDF]

				D. R. Carrier, K. Chase, and K. G. Lark Genetics of canid skeletal variation: Size and shape of the pelvis Genome Res., December 1, 2005; 15(12): 1825 - 1830. [Abstract] [Full Text] [PDF]

				M. F. Allan, E. J. Eisen, and D. Pomp Genomic Mapping of Direct and Correlated Responses to Long-Term Selection for Rapid Growth Rate in Mice Genetics, August 1, 2005; 170(4): 1863 - 1877. [Abstract] [Full Text] [PDF]

				N. Yi, B. S. Yandell, G. A. Churchill, D. B. Allison, E. J. Eisen, and D. Pomp Bayesian Model Selection for Genome-Wide Epistatic Quantitative Trait Loci Analysis Genetics, July 1, 2005; 170(3): 1333 - 1344. [Abstract] [Full Text] [PDF]

				N. C. Jerez-Timaure, E. J. Eisen, and D. Pomp Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2 Physiol Genomics, May 11, 2005; 21(3): 411 - 422. [Abstract] [Full Text] [PDF]

				T. A. Dragani 10 Years of Mouse Cancer Modifier Loci: Human Relevance Cancer Res., June 15, 2003; 63(12): 3011 - 3018. [Abstract] [Full Text] [PDF]