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Physiol. Genomics 1: 151-163, 1999. First published November 11, 1999;
1094-8341/99 $5.00
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Physiological Genomics 1:151-163 (1999)
1094-8341/99 $5.00 © 1999 American Physiological Society

Review

Physiological consequences of ectopic agouti gene expression: the yellow obese mouse syndrome

GEORGE L. WOLFF1,2,3, DEAN W. ROBERTS1,3 and KATHLEEN G. MOUNTJOY4

1 Division of Biochemical Toxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson 72079
2 Department of Biochemistry/Molecular Biology
3 Department of Pharmacology/Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205
4 Research Centre for Developmental Medicine and Biology and Department of Molecular Medicine, University of Auckland, Auckland 1, New Zealand

Wolff, George L., Dean W. Roberts, and Kathleen G. Mountjoy. Physiological consequences of ectopic agouti gene expression: the yellow obese mouse syndrome. Physiol. Genomics 1: 151–163, 1999.—This review summarizes primary and downstream phenotypic manifestations, with emphasis on altered responsiveness to environmental stimuli, of dominant yellow mutations at the mouse agouti locus. Obvious effects include hyperinsulinemia, obesity, stimulation of somatic growth and tumorigenesis, and coat color. Downstream influences of hyperinsulinemia and obesity on the individual's physiology determine important components of the obese yellow agouti mouse syndrome. Collectively, the phenotypic aberrations described support the concept that identical genomes are expressed in a spectrum of physiological phenotypes that reflect the complex interdependence of gene-regulated physiological pathways and processes in the organism throughout extended, but temporally ordered, periods of fetal and neonatal development and aging. This summary identifies important areas for additional research and provides integrated information required for a systematic approach to the development of interventions for common adult human health problems.

background genome; melanocortin; pseudoagouti mice; response to environmental stimuli; tumorigenesis




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