Physiol. Genomics Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiol. Genomics 1: 127-138, 1999.
1094-8341/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KIM, J.
Right arrow Articles by PELLETIER, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KIM, J.
Right arrow Articles by PELLETIER, J.
Received 6 July 1999; accepted in final form 1 September 1999.
Physiological Genomics 1:127-138 (1999)
1094-8341/99 $5.00 © 1999 American Physiological Society

Review

Molecular genetics of chromosome translocations involving EWS and related family members

JUNGHO KIM 1 and JERRY PELLETIER 1,2

1 Department of Biochemistry
2 Department of Oncology, McGill University, Montreal, Quebec, Canada H3G 1Y6

Kim, Jungho, and Jerry Pelletier. Molecular genetics of chromosome translocations involving EWS and related family members. Physiol. Genomics 1: 127–138, 1999.—Many types of sarcomas are characterized by specific chromosomal translocations that appear to result in the production of novel, tumor-specific chimeric transcription factors. Many of these show striking similarities: the emerging picture is that the amino-terminal domain of the fusion product is donated by the Ewing's sarcoma gene (EWS) or a related member from the same gene family, whereas the carboxy-terminal domain often consists of a DNA-binding domain derived from one of a number of transcription factors. Given the observation that the different translocation partners of the EWS protooncogene are associated with distinct types of sarcomas, the functional consequence of fusing EWS (or a related family member) to a different DNA-binding domain can only be understood in the context of functional studies that define the specificity of action of the different fusion products. An understanding of the molecular structure and function of these translocations provides new methods for diagnosis and novel targets for therapeutics.

EWS; oncogene; transformation; cancer genetics




This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
F. I. J. Crawford, C. L. Hodgkinson, E. Ivanova, L. B. Logunova, G. J. Evans, S. Steinlechner, and A. S. I. Loudon
Influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus)
Physiol Genomics, November 14, 2007; 31(3): 521 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
Y. Iwamoto
Diagnosis and Treatment of Ewing's Sarcoma
Jpn. J. Clin. Oncol., February 1, 2007; 37(2): 79 - 89.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. P. Ng, G. Potikyan, R. O. V. Savene, C. T. Denny, V. N. Uversky, and K. A. W. Lee
Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins
PNAS, January 9, 2007; 104(2): 479 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Alex and K. A. W. Lee
RGG-boxes of the EWS oncoprotein repress a range of transcriptional activation domains
Nucleic Acids Res., March 2, 2005; 33(4): 1323 - 1331.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. M. Townson, K. Kang, A. V. Lee, and S. Oesterreich
Structure-Function Analysis of the Estrogen Receptor {alpha} Corepressor Scaffold Attachment Factor-B1: IDENTIFICATION OF A POTENT TRANSCRIPTIONAL REPRESSION DOMAIN
J. Biol. Chem., June 18, 2004; 279(25): 26074 - 26081.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Araya, K. Hirota, Y. Shimamoto, M. Miyagishi, E. Yoshida, J. Ishida, S. Kaneko, M. Kaneko, T. Nakajima, and A. Fukamizu
Cooperative Interaction of EWS with CREB-binding Protein Selectively Activates Hepatocyte Nuclear Factor 4-mediated Transcription
J. Biol. Chem., February 7, 2003; 278(7): 5427 - 5432.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Laflamme, C. Filion, J. A. Bridge, M. Ladanyi, M. B. Goldring, and Y. Labelle
The Homeotic Protein Six3 Is a Coactivator of the Nuclear Receptor NOR-1 and a Corepressor of the Fusion Protein EWS/NOR-1 in Human Extraskeletal Myxoid Chondrosarcomas
Cancer Res., January 15, 2003; 63(2): 449 - 454.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online