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Physiol. Genomics 1: 119-125, 1999.
1094-8341/99 $5.00
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Received 19 April 1999; accepted in final form 5 August 1999.
Physiological Genomics 1:119-125 (1999)
1094-8341/99 $5.00 © 1999 American Physiological Society

Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains

YASSER SAAD, MICHAEL R. GARRETT, SOON JIN LEE, HOWARD DENE and JOHN P. RAPP

Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614-5804

Saad, Yasser, Michael R. Garrett, Soon Jin Lee, Howard Dene, and John P. Rapp. Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains. Physiol. Genomics 1: 119–125, 1999.—We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F2 population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic strain introgressing a large 118-centimorgan (cM) segment of LEW chromosome 1 into the S background had been constructed. This initial congenic strain had a reduced blood pressure compared with S rats, proving the existence of a blood pressure QTL, but not giving a good localization of the QTL. In the present work a series of five overlapping congenic substrains were produced from the original congenic strain in order to localize a blood pressure QTL to a 25-cM region near the center of chromosome 1. The congenic substrains also ruled out the Sa locus as a blood pressure QTL in the S vs. LEW comparison because the Sa locus was contained in a congenic substrain that did not alter blood pressure.

Sa gene; genetic hypertension; salt-sensitive hypertension; cardiac hypertrophy




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